Optimization of Mixed Solid-state Fermentation of Soybean Meal by Lactobacillus Species and Clostridium butyricum

Soybean meal is the main vegetable protein source in animal feed. Soybean meal contains several anti-nutritional factors, which directly affect digestion and absorption of soy protein, thereby reducing growth performance and value in animals. Fermented soybean meal is rich in probiotics and functional metabolites, which facilitates soybean protein digestion, absorption and utilization in piglets. However, the mixed solid-state fermentation (SSF) conditions of soybean meal remain to be optimized. In this study, we investigated the optimal parameters for SSF of soybean meal by Lactobacillus species and Clostridium butyricum. The results showed that two days of fermentation was sufficient to increase the viable count of bacteria, lactic acid levels and degradation of soybean protein in fermented soybean meal at the initial moisture content of 50%. The pH value, lowering sugar content and oligosaccharides in fermented soybean meal, was significantly reduced at the initial moisture content of 50% after two days of fermentation. Furthermore, the exogenous proteases used in combination with probiotics supplementation were further able to enhance the viable count of bacteria, degradation of soybean protein and lactic acid level in the fermented soybean meal. In addition, the pH value and sugar content in fermented soybean meal were considerably reduced in the presence of both proteases and probiotics. Furthermore, the fermented soybean meal also showed antibacterial activity against Staphylococcus aureus and Escherichia coli. These results together suggest that supplementation of both proteases and probiotics in SSF improves the nutritional value of fermented soybean meal and this is suitable as a protein source in animal feed

EFFECT OF EIGHT WEEKS VIBRATION TRAINING ON THE LOWER LIMB BASIC ABILITY AND ATHLETIC PERFORMANCE OF GYMNASTS

The purpose of this study explores the effects of 8 weeks vibration training on the basic ability (explosive power, speed, agility) and athletic performance (backward somersault) of the lower limbs of gymnasts. Sixteen gymnasts were randomly divided into vibration training group (VT) and control group (CON). Participants were trained for eight weeks and performed countermovement jump (CMJ), sprints, shuttle run, and backward somersault tests before the training, after 4 weeks, and 8 weeks of training. The significant level was set to α = .05. The results showed that the speed of VT increased significantly after 4 weeks of training, and the speed and agility of VT increased significantly after 8 weeks of training (p \u3c.05). In conclusion, Gymnasts can improve their speed ability through 4 weeks of vibration training, and 8 weeks vibration training can improve their speed and agility

Interactions between Amyloid-β and Hemoglobin: Implications for Amyloid Plaque Formation in Alzheimer's Disease

Accumulation of amyloid-β (Aβ) peptides in the brain is one of the central pathogenic events in Alzheimer's disease (AD). However, why and how Aβ aggregates within the brain of AD patients remains elusive. Previously, we demonstrated hemoglobin (Hb) binds to Aβ and co-localizes with the plaque and vascular amyloid deposits in post-mortem AD brains. In this study, we further characterize the interactions between Hb and Aβ in vitro and in vivo and report the following observations: 1) the binding of Hb to Aβ required iron-containing heme; 2) other heme-containing proteins, such as myoglobin and cytochrome C, also bound to Aβ; 3) hemin-induced cytotoxicity was reduced in neuroblastoma cells by low levels of Aβ; 4) Hb was detected in neurons and glial cells of post-mortem AD brains and was up-regulated in aging and APP/PS1 transgenic mice; 5) microinjection of human Hb into the dorsal hippocampi of the APP/PS1 transgenic mice induced the formation of an envelope-like structure composed of Aβ surrounding the Hb droplets. Our results reveal an enhanced endogenous expression of Hb in aging brain cells, probably serving as a compensatory mechanism against hypoxia. In addition, Aβ binds to Hb and other hemoproteins via the iron-containing heme moiety, thereby reducing Hb/heme/iron-induced cytotoxicity. As some of the brain Hb could be derived from the peripheral circulation due to a compromised blood-brain barrier frequently observed in aged and AD brains, our work also suggests the genesis of some plaques may be a consequence of sustained amyloid accretion at sites of vascular injury

Enhancing the Insulation of Wide-Range Spectrum in the PVA/N Thin Film by Doping ZnO Nanowires

In this study, polyvinyl alcohol/nitrogen (PVA/N) hybrid thin films doped with sharp-sword ZnO nanowires with insulating effect and wide-range spectrum are demonstrated for the first time. PVA/N doped ZnO nanocomposites were developed by blending PVA and N-doped ZnO nanowires in water at room temperature. Measurements from the field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Raman, and photoluminescence emission (PL) spectra of the products show that nitrogen is successfully doped into the ZnO wurtzite crystal lattice. In addition, the refractive index of PVA/N doped ZnO hybrid thin films can be controlled by varying the doped ZnO nanowires under different NH3 concentrations. It is believed that PVA/N doped ZnO hybrid thin films are a suitable candidate for emerging applications like heat-shielding coatings on smart windows

Energy dissipation behaviours and seismic reduction performance of a proposed velocity and displacement dependent hydraulic damper (VDHD)

A new oil‐pressure Velocity and Displacement Dependent Hydraulic Damper (VDHD) is proposed by adding an additional Relief Valve parallel to the Throttle Valve with a different aperture size. This objective is to obtain an adaptive control by changing the damping coefficient of the VDHD for better control of structural movement during earthquake. In order to simulate its actual energy elimination, a mathematical analysis model is developed based on the Maxwell Model, which is modified by adding a serial friction model and a small damper parallel to the friction model in this study. The mathematical simulated results are compared with the actual energy‐dissipating behaviours of this proposed damper. The comparison shows that this proposed mathematical modelling could accurately simulate the relation of force and displacement as well as the relation of force and velocity during the process of energy dissipation. In addition, results of both the laboratory shaking table test and simulation analyses are used to test and verify the seismic reduction performance of this proposed damper. The experimental and simulation results show that in spite of the magnitude of the earthquake, the proposed VDHD device has a superior effect on the control of structural displacement by achieving effective acceleration reduction. Santrauka Siūlomas naujas hidraulinis i greiti ir poslinki reaguojantis slopintuvas (HGPS), sukurtas prie droselinio vožtuvo su kintama apertūra pridejus atbulini vožtuva. Buvo siekiama užtikrinti geresne adaptyvia konstrukcijos judejimo žemes drebejimo metu kontrole keičiant HGPS slopinimo koeficienta. Norint modeliuoti tikraji energijos pašalinima, buvo sukurtas matematinis modelis, pagristas Maksvelo modeliu. Šis modelis buvo pakeistas prie trinties modelio pridejus nuosekluji trinties modeli ir nedideli slopintuva. Matematinio modeliavimo rezultatai lyginami su tikraja siūlomo gesintuvo energijos sklaida. Palyginimas rodo, kad matematinio modeliavimo rezultatai atitinka tikraja siūlomo gesintuvo elgsena. Lyginant skaičiavimo rezultatus su eksperimentiniais matyti, kad siūlomas matematinis modeliavimas leidžia tiksliai išreikšti jegos ir poslinkio bei jegos ir greičio ryšius, susidarančius energijos sklaidos metu. Laboratoriniai rezultatai, gauti naudojant vibracini stala, ir modeliavimo rezultatai taikomi tirti bei tikrinti siūlomo gesintuvo itaka mažinant seismines konstrukcijos charakteristikas. Eksperimentiniai ir modeliavimo rezultatai rodo, kad nepaisant žemes drebejimo laipsnio, siūlomas gesintuvas labai pagerina konstrukcijos poslinkiu kontrole efektyviai mažindamas judejimo pagreiti. First Published Online: 10 Feb 2011 Reikšminiai žodžiai: HGPS, Maksvelo modelis, diskretusis sprendinys, pasyvusis energijos skaidos prietaisas, vibracinio stalo bandymas, modeliuojamas konstrukcijos reakcijos mažinima

RISK OF SLEEP DISORDERS IN PATIENTS WITH DECOMPRESSION SICKNESS: A NATIONWIDE, POPULATION-BASED STUDY IN TAIWAN

Background: Decompression sickness (DCS) primarily manifests musculoskeletal pain, cutaneous manifestations, lymphatic symptoms, and neurological symptoms. DCS might affect the central nervous system and induce the stress in the patients, but few studies about the psychiatric morbidity after DCS have been conducted. This study aimed to investigate the association between DCS and the risk of developing psychiatric disorders. Subjects and methods: This study was a population-based, matched cohort design. A total of 738 enrolled patients, with 123 study subjects who had suffered from DCS, and 615 controls matched for sex and age, from the Longitudinal Health Insurance Databank from 2000-2010 in Taiwan, and selected from the National Health Insurance Research Database. After adjusting for the confounding factors, Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 10 years of follow-up period. Results: Of the study subjects, 10 (8.13%) developed psychiatric disorders when compared to 35 (5.69%) in the control group. The study subjects were more likely to develop psychiatric disorders (crude hazard ratio [HR]: 2.79 (95% CI=1.37-5.69, P<0.01). After adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities, the adjusted HR was 3.83 (95% CI=1.60-9.16, P<0.01). Sleep disorders was associated with DCS with the adjusted HR as 5.74 (95% CI=1.04-31.56, P<0.01). Hyperbaric oxygenation therapy was not associated with a lower risk of psychiatric disorders. Conclusions: Patients who suffered from DCS have a 3.8-fold risk of developing psychiatric disorders, and a 5.7-fold risk of sleep disorders. This finding is a reminder for the clinicians that a regular psychiatric follow-up might well be needed for these patients

Developing a neutral equilibrium device as dynamic virtual piers for an emergency relief bridge

Every year, many natural disasters strike Taiwan, destroying bridges and disrupting traffic. To allow shipping of relief provisions and salvage, fabricated steel bridges are often used to construct emergency relief bridges. This kind of bridge must meet strength and functionality requirements. Strength depends on the materials used, while functionality depends on displacement control. These two requirements affect the section design of the bridge deck. In order to quickly build a light-weight bridge for emergency relief with displacement control, a neutral equilibrium mechanism is proposed and developed to control the deflection of an emergency relief bridge. A neutral equilibrium mechanism is a system with an internal control mechanism that can actively change the internal structure. Structural transformation causes the size variation of the action force to respond to continuous changes in bridge deflection. This mechanism can expand the effective span of the bridge, maintain its strength and functionality, and increase the convenience of building and mobility. Experimental results reveal that a virtual pier at the center of a bridge with this proposed mechanism installed can control vertical deflection caused by vehicles carrying heavy loads. Test and analysis records also reveal that the vertical displacement at the center of a bridge with the neutral equilibrium mechanism installed is close to zero. The practicality of this neutral equilibrium mechanism has been verified by experiment

Management and control of coccidiosis in poultry — A review

Poultry coccidiosis is an intestinal infection caused by an intracellular parasitic protozoan of the genus Eimeria. Coccidia-induced gastrointestinal inflammation results in large economic losses, hence finding methods to decrease its prevalence is critical for industry participants and academic researchers. It has been demonstrated that coccidiosis can be effectively controlled and managed by employing anticoccidial chemical compounds. However, as a result of their extensive use, anticoccidial drug resistance in Eimeria species has raised concerns. Phytochemical/herbal medicines (Artemisia annua, Bidens pilosa, and garlic) seem to be a promising strategy for preventing coccidiosis, in accordance with the “anticoccidial chemical-free” standards. The impact of herbal supplements on poultry coccidiosis is based on the reduction of oocyst output by preventing the proliferation and growth of Eimeria species in chicken gastrointestinal tissues and lowering intestinal permeability via increased epithelial turnover. This review provides a thorough up-to-date assessment of the state of the art and technologies in the prevention and treatment of coccidiosis in chickens, including the most used phytochemical medications, their mode of action, and the applicable legal framework in the European Union